Senior Human Resources Business Partner

Job Description
Job Description
POSITION SUMMARY
The
Senior HR Business Partner
(Sr. HRBP) serves as a strategic and hands-on partner to leaders across Nucleus RadioPharma, helping to build the people infrastructure needed to scale a fast-growing, GMP-regulated radiopharmaceutical organization. This role owns full-spectrum HR partnership – talent, employee relations, performance, organizational design, HR operations, and policy – ensuring HR practices are consistent, compliant, and aligned to Nucleus's operating rhythm. This is a builder role as much as a partner role: the Sr.

HRBP will help stand up scalable HR processes and frameworks appropriate for a ~55-person startup operating in an IND/FDA-regulated, GMP environment, while maintaining the flexibility and responsiveness leaders expect at this stage of growth. PRINCIPAL RESPONSIBILITIES
HR Business Partnership
Serve as the primary day-to-day HR partner for assigned leaders and employees, providing practical guidance on employee relations, performance management, attendance, workplace concerns, team dynamics, and policy application.

Meet regularly with leaders to review staffing needs, employee performance, open positions, retention risks, organizational changes, and emerging people issues. Track agreed-upon actions through completion. Translate business and operational priorities into specific HR actions, including hiring plans, onboarding, training, performance expectations, development plans, succession planning, and employee communications.

Support organizational changes by drafting job descriptions, teaching, coaching and clarifying responsibilities, evaluating reporting relationships, updating organizational charts, and coordinating employee communications and implementation steps. Partner with leaders to identify workforce gaps, develop staffing plans, and ensure the organization has the appropriate roles, capabilities, and coverage to support operational and regulatory requirements.

Coach managers on setting clear expectations, providing timely feedback, documenting performance concerns, developing corrective action plans, and addressing issues consistently and promptly. Monitor employee trends, including turnover, engagement, absenteeism, performance concerns, and staffing levels, and recommend specific actions based on the data. Coordinate closely with Talent Acquisition, Payroll, Benefits, Legal, and HR Operations to ensure employee matters and organizational changes are implemented accurately and on time.

Employee Relations & Compliance
Manage, coach on employee relations matters with sound judgment, consistency, and appropriate documentation, escalating and coordinating with leadership as needed. Ensure HR policies, practices, and documentation meet the standards required in a GMP and FDA-regulated environment. Maintain compliant, audit-ready HR documentation and recordkeeping practices. Talent Management & Performance
Support onboarding and workforce planning efforts in partnership with hiring managers as Nucleus scales.

Facilitate performance management processes, including goal-setting, feedback cycles, and performance improvement support. Partner with leaders on succession planning, career pathing, and talent development for key roles. Recruiting & Talent Acquisition
Own full-cycle recruiting for assigned functions – intake, job posting, sourcing, screening, interviewing, and offer negotiation – in partnership with hiring managers. Build and maintain a scalable recruiting process and candidate pipeline appropriate for a fast-growing, GMP-regulated organization.

Partner with hiring managers to define role requirements, build structured interview plans, and calibrate candidate evaluation criteria. Ensure recruiting practices, interview documentation, and offer processes meet compliance and audit-readiness standards. Manage the candidate experience end-to-end, ensuring timely communication and a smooth handoff into onboarding. Track recruiting metrics (e.g., time-to-fill, pipeline health) and report on hiring progress to support workforce planning and leadership visibility.

Support employer branding and sourcing strategies to attract talent in a competitive life sciences/radiopharmaceutical labor market. HR Operations
Own day-to-day HR operations, including HRIS data integrity, employee records, and personnel file management. Administer onboarding and offboarding logistics, ensuring a consistent, compliant experience for new hires and departing employees. Maintain and administer HR policies and the employee handbook, ensuring version control and timely updates.

Own benefits administration, including enrollment, eligibility, and day-to-day employee questions, in partnership with brokers/vendors. Lead annual open enrollment: coordinate timelines, communications, and vendor logistics, and ensure employees have the information needed to make informed elections. Maintain headcount tracking, org charts, and reporting for leadership visibility. Ensure HR operational processes and recordkeeping meet GMP/FDA audit-readiness standards.

QUALIFICATIONS & REQUIREMENTS
Required:
Bachelor’s Degree in Business Administration, Psychology or another related field
5+ years of experience as an HR Business Partner or similar HR generalist/strategic role.
3+ years of full cycle recruiting experience
Demonstrated experience managing employee relations matters with discretion and sound judgment. Experience owning HR operations, including HRIS administration, records management, onboarding/offboarding, and benefits/open enrollment administration.

Strong written and verbal communication skills; comfortable partnering with senior leadership. Ability to operate with both strategic perspective and hands-on execution in a fast-paced, resource-lean environment. Ability to work onsite in Rochester, MN, with 1–2 trips per month to other Nucleus onsite locations OR if remote, willing to travel onsite to Rochester, MN for two weeks per month
Strong verbal and written communication skills. Demonstrated problem-solving and interpersonal skills, utilizing resourceful thinking and strong empathy.

Ability to foster an inclusive and cooperative work environment.

Preferred

Experience in a life sciences, pharmaceutical, biotech, or GMP-regulated environment. Familiarity with FDA/IND regulatory context as it pertains to workforce and documentation requirements. Experience with HRIS platforms and HR operations tools. SHRM-CP/SCP, PHR/SPHR, or equivalent certification
Comfort using AI-enabled HR and HRIS tools to improve efficiency, with sound judgment about human review of any compliance-sensitive or employee-facing output. Experience with HR strategy and tactical HR operations work spanning both fields.

Strong employee relations focus, with demonstrated experience handling complex or sensitive matters independently
Ideal:
Experience with HR Strategy and Tactical HR Operation work
Strong employee relations focus
HRIS Experience
COMPENSATION & BENEFITS
The salary range for this role in Minnesota is $110,00-$135,000 per year. Please note that compensation may vary outside of this range depending on several factors, including but not limited to a candidate’s qualifications, skills, competencies, and experience.

Benefit packages for this role include medical, dental, and vision insurance, as well as a Health Savings Account or Flexible Spending Account options (depending on the plan chosen), and 401k retirement account access with employer matching. Team members in this role are also entitled to paid sick leave and/or other paid time off in compliance with applicable law. Relocation assistance is available to qualified team members.

This job description is a summary of the typical functions of the position, not necessarily an exhaustive or comprehensive list of all possible position responsibilities, tasks, and duties. The company reserves the right to assign or reassign duties and responsibilities to this job at any time. This job does not constitute a written or implied contract of employment; employment remains “at-will.”
Nucleus RadioPharma is an equal opportunity employer and believes everyone deserves respect, dignity, and equality.

All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.