Scientist II - LNP Formulation

Title: Scientist II - LNP Formulation
Description: Onsite: San Diego, CA. No relocations.

Position Summary
We are seeking a motivated and detail-oriented Scientist 1 to join our Formulation team. In this hands-on laboratory role, you will work closely with senior scientists to execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery. The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform.

Responsibilities

Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) or targeted lipid nanoparticle (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies under the minor guidance of senior formulation scientists. Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters. Collaborate cross-functionally with internal teams to support and fulfill formulation requests.

Support early-stage formulation development and downstream processing activities when needed, including cryoprotection, scale-up, and stability studies. Maintain detailed records documenting formulation activities and results. Analyze, interpret, and present experimental data to the formulation team. Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.

Requirements, Knowledge, Skills, and Abilities

Education: Bachelors degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience, OR a Masters degree with 2+ years of industry experience.

LNP Expertise: Minimum of 2 years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).

Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.

Software & Data: High proficiency in MS Excel is required; hands-on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred.

Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast-paced team environment.

Preferred Skills: Prior experience with targeted LNP preparation (mAb, Fab, ScFv, VHH coated LNP) and immune cell delivery is highly desirable.