(Senior) RA, Chemistry

About Nosis Bio:

Nosis Bio is a well-funded biotech startup exclusively focused on cell-specific delivery of RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts that believe targeted extrahepatic delivery is the only thing preventing RNA therapies from becoming the standard-of-care for most chronic diseases. We combine deep expertise in receptor biology, generative AI, and high throughput in vivo data generation to exponentially accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech.

About the Role:

We are seeking a RA / Sr. RA to conduct chemical synthesis, chromatographic purification and biochemical validation of peptides, oligonucleotides and oligo-peptide conjugates to advance therapeutic candidates. The successful candidate will have hands-on experience with peptide chemistry and will work closely with multidisciplinary teams to support various drug discovery projects.

Responsibilities:

● Perform peptide synthesis on automated synthesizers (Multi Pep, Liberty Prime)

● Perform HPLC purification and MS analysis of synthesized products

● Perform in vitro biochemical assays with peptides, oligonucleotides and proteins

● Maintenance of chemistry instruments and supplies

What we’re looking for:

● Ability to work on site in our lab spaces located in the Research Park at Marina Village (Alameda, CA)

● Experience with solid phase peptide synthesis and downstream processing (cleavage, deprotection and purification)

● Experience with performing in vitro biochemical assays

● Direct experience with automated peptide synthesizers (Multi Pep and Liberty Prime) highly preferred

● Experience with high-throughput screening highly preferred

● Nice to have but not required: Previous experience with solid phase oligonucleotide synthesis, purification and conjugation

● Motivated and proactive with strong problem-solving skills

● Ability to multitask and manage several projects simultaneously

● Team-oriented and open to collaboration across scientific disciplines

● Title is dependent on academic and professional experience – we recruit diverse backgrounds including those with academic, non-profit, and industry experiences