Principal Scientist, Biomarker Development

Scholar Rock is delivering muscle-targeted breakthroughs to transform the treatment of spinal muscular atrophy (SMA) and other rare neuromuscular diseases where muscle atrophy remains a critical unmet need.

As a global leader in myostatin biology, a field focused on proteins that regulate muscle mass, the biopharmaceutical company is named for the visual resemblance of a scholar rock to protein structures. Our commitment to unlock fundamentally different treatment approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. Scholar Rock works every day to create new possibilities for patients through its highly innovative anti-myostatin program, including opportunities in additional rare neuromuscular diseases. Learn more about our neuromuscular franchise at ScholarRock.com and follow @ScholarRock on X and on LinkedIn.

Scholar Rock is seeking an accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific leadership for biomarker strategy and execution across preclinical programs in neuromuscular disease. Reporting to the Senior Director, Head of Biomarker Development, this individual will support the discovery, development, and implementation of fit-for-purpose biomarker approaches that enable translation from discovery through early clinical development.

The Principal Scientist will serve as a subject matter expert in biomarker and translational science, partnering closely with Discovery Biology, Bioanalytical, and Clinical Pharmacology and other cross-functional stakeholders. This individual will be responsible for developing biomarker strategies, defining context-of-use, guiding assay development and data generation, interpreting biomarker data, and contributing to program strategy.

The successful candidate will bring deep scientific expertise, strong strategic thinking, and hands-on experience translating biological hypotheses into clinically actionable biomarker approaches. They will integrate discovery, translational, and clinical perspectives to support assessment of target engagement, pharmacodynamic response, and neuromuscular disease biology and progression.

Position Responsibilities: