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Principal Scientist (Comp. Bio/ML) - Director Level

HelicalLondon, England🇬🇧United KingdomPosted 20 Aug 2026

Why This Role Stands Out

This Director-level Principal Scientist role offers a unique opportunity to lead the application of cutting-edge foundation models in drug development, fostering significant career growth and impact within a reputable company. If you are a seasoned computational biologist or ML expert passionate about translating complex science into real-world solutions and enjoy a dynamic, collaborative environment, this hybrid position is an excellent fit for your ambition. Apply today to shape the future of translational research!

Quick Overview

Seniority
Mid Senior
Employment type
Full Time
Work mode
Hybrid
Location
London, England, United Kingdom
Posted
3 weeks ago
Machine LearningBusiness DevelopmentPyTorch

Job Description

We’re looking for a Principal Computational Scientist/Director to help translate our foundation models into impactful, real-world discovery workflows. In this role, you’ll provide scientific leadership across model evaluation and applied use cases, ensuring our work stays grounded in the most relevant challenges in drug development and translational research.

You’ll join as a senior individual contributor with leadership and strategy experience at a point where the the team scales. You will act as a key scientific partner to our research team, mentor and support junior colleagues, and work closely with Product and Business Development to turn cutting-edge biology + ML into deliverables that matter for customers.

  • PhD in Computational Biology, Machine Learning, Bioinformatics, or a related field, with a strong focus on Transcriptomics OR Genomics + ML, and 2+ years of industry (non-academic) experience OR MSc in a relevant field and 5+ years of industry experience applying ML to Transcriptomics OR Genomics problems
  • Strong understanding of ML/AI methods for biological data (e.g., transformers, VAEs, diffusion models, classical ML)
  • Hands-on experience with modern ML frameworks such as PyTorch (or equivalent)
  • Leadership experience with small teams to work towards defined roadmaps or projects
  • Excellent communication skills — able to translate complex science into clear, actionable insights for technical and non-technical stakeholders
  • Comfortable in a fast-paced, high-iteration environment, moving quickly from prototype → experiment → insight
  • Strong passion for building at the intersection of biology and machine learning

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