Synthetic Chemist

Job ID: 8280

Req ID: 881

Location: Alnwick NE66, UK

Posted:

Job Family: No Longer In Use

Pay Type: Salary

The Role

This is an exciting opportunity to take ownership of synthesis projects from planning through to delivery, working in line with company procedures and regulatory requirements including GMP and IRR17. You’ll also play a key client-facing role, representing the IL team in project meetings and helping to ensure projects are delivered successfully.

Main tasks and responsibilities

• Capable of managing small projects with assistance from more experienced colleagues.
• Represent IL team in project meetings with Clients and provide regular progress updates. Communication will primarily be through more experienced colleagues.
• Ensure that work awarded is progressed and reported to the expected quality standards / schedule.
• Plan and perform syntheses / purifications of various chemical and/or labelled entities within agreed timeframes. Apply isotope chemistry knowledge to the development of products that meet the expected target product profile, taking into account scalability, safety and cost of goods for the proposed route.
• Ensure, where required, that laboratory work and associated documentation complies with GMP or other regulatory requirements, internal policies/procedures and client requirements.
• Produce and review GMP compliant Batch Synthesis Instructions (BSIs) and other process documentation.
• Perform in-process analytical testing where relevant and/or ensure that analytical, microbiological (where relevant) and materials science/spectroscopic testing needs are discussed and agreed with the QC / Micro teams.
• Prepare data packages on such chemical entities so that the identity of same should be considered conclusively proven. Provide written reports to clients as necessary. Archive data after completion of the project.
• Maintain laboratory notebook (LNB), ensuring raw data is included and annotated. LNBs to be countersigned on a regular basis and contribute to countersigning others’ books as assigned.
• Work with due regard to Health & Safety of self and others.
• Work flexibly across the site to meet business needs.

Qualifications and experience required for competent performance

• An excellent record in synthetic organic chemistry, either at Doctoral level or Graduate with minimum of one year’s relevant industrial experience. Knowledge and experience of synthetic chemistry covering route selection.
• A good understanding of process analytical chemistry, impurity control and/or sufficient analytical skills to conduct in-process testing and a good understanding of the factors controlling API physical form.
• Will require training on radiochemistry ( 14 C and synthesis / compliance techniques). Requires regular supervision from People Manager and mentoring from designated team members.
• Good written and oral communication skills.

• Competent in the use of Microsoft Office packages including Word, Excel, etc.