Scientist/Senior Scientist, High-Throughput Screening

About the Role

We are seeking a Scientist/Senior Scientist, High-Throughput Screening to manage the day-to-day execution of our cryoprotectant screening program. You will be responsible for improving an established screening workflow, increasing throughput, identifying less-toxic formulations, and advancing our understanding of how cryoprotectants affect cell viability and function.

Working closely with assay scientists, biologists, and automation engineers, you will integrate primary cells and iPSC-derived models into scalable screening workflows. You will develop mechanism-of-action assays, investigate cellular mechanisms of toxicity. This role combines hands-on experimental work, team coordination, and responsibility for delivering screening milestones that support organ-scale reversible cryopreservation.

You Will

• Coordinate the screening team’s day-to-day work, plan experiments, mentor team members, and ensure timely delivery of screening milestones.

• Manage and improve the screening workflow from cell-culture readiness and HTS assay execution through data analysis, quality control, and interpretation.

• Increase screening throughput and reproducibility in partnership with automation engineers while maintaining biological relevance and data quality.

• Design and execute functional assays to characterize cellular responses following cryoprotectant exposure.

• Develop and validate mechanism-of-action assays to identify drivers of toxicity and guide the design of less-toxic formulations.

• Improve the integration of renal, cardiac, and hepatic cell models using primary cells or iPSC-derived cells into the screening pipeline.

• Use chromatography and mass spectrometry to assess the purity of compounds used in cryoprotectant screening.

• Analyze multiparametric datasets, prioritize findings for follow-up, and communicate actionable recommendations to colleagues developing cryoprotectant formulations.

You Are

• Trained at the PhD level in Toxicology, Pharmacology, Cell Biology, Physiology, Bioengineering, Chemical Engineering, Tissue Engineering, or a related field, or bring equivalent expertise through at least four years of relevant experience managing research projects end to end.

• Experienced in independently designing, executing, and improving cell-based high-throughput screening workflows.

• Skilled in assay development using primary cells or iPSC-derived cells, with experience in at least one renal, cardiac, or hepatic model.

• Experienced in developing mechanistic assays and translating screening results into testable hypotheses about cellular toxicity.

• Comfortable working hands-on with plate-based assays, imaging, flow cytometry, and analytical chemistry methods such as HPLC, LC-MS, or GC-MS for compound purity assessment.

• Experienced in quantitative analysis of screening data, including quality control, statistical interpretation, and analysis of multiple experimental readouts.

• Able to coordinate and mentor a scientific team, manage interdependent workflows, and take responsibility for experimental execution and outcomes.

• Collaborative, receptive to diverse perspectives, and comfortable adapting priorities in a fast-paced, mission-driven research environment.

Preferred Qualifications

• Experience scaling automated screening workflows in close partnership with lab automation engineers.

• Experience integrating iPSC-derived cells or advanced 3D models into high-throughput screening pipelines.

• Experience with high-content imaging, transcriptomics, or other approaches that connect cellular phenotypes to mechanisms of toxicity.

• Proficiency in Python or R for analysis, visualization, and interpretation of complex screening datasets.

• Experience relating compound purity measurements to biological assay results.

Benefits

• Generous medical, dental and vision insurance coverage

• Flexible time off and paid holidays

• Competitive compensation package, including salary and equity

• Access to a 401(k) retirement savings plan

• FSA and commuter benefits

• Daily lunch and dinners, plus a variety of snacks

• Monthly learning stipend

• On-site fitness center

• Quarterly team social budget