Researcher - Protein Metrology

LGC provides a range of measurement products and services which underpin the safety, health and security of the public, including reference materials and proficiency testing, genomics solutions, services and instrumentation, and expert sample analysis and interpretation. Our customers are across a number of end markets including Government, Academia, Pharmaceuticals, Agriculture, Biotechnology, Food and Environment. 

The Protein Mass Spectrometry team delivers high quality measurement research projects to meet current and future analytical challenges as part of the LGC’s international role as the UK’s National Measurement Laboratory and Designated Institute (DI) for chemical and bio-measurement.   

The job holder will help develop and validate analytical methods to support NML measurement research programmes for government. They will also assist private sector R&D contract commitments related to protein analysis. They must use advanced instruments and apply various sample preparation techniques as needed.

The successful candidate will have experience in protein structural characterisation and, likely quantification by mass spectrometry. Training as needed will be provided on traceability of measurements to the System of International Units and on the instruments necessary for the delivery of the projects. This is an excellent opportunity for candidates seeking to advance their career in protein mass spectrometry.

Key Responsibilities

• Independent day-to-day planning and delivery of challenging research and development work, ensuring quality, timely delivery, and adherence to budget
• Lead and manage protein and peptide metrology projects, concentrating on protein structural analysis through mass spectrometry
• Publication and dissemination of scientific advancements and achievements
• Provide support in formulating R&D commercial contracts
• Build and nurture relationships with external partners and collaborators, and extend metrology networks to underpin the UK national measurement system
• Delivery of ad-hoc research commercial projects and comprehensive reporting of results

Knowledge, Experience and Technical Skills

• PhD (or equivalent experience) in industry, academic, or clinical research
• Demonstrated expertise in protein structure characterization methods involving mass spectrometry, such as HDX-MS, native MS, IMS, and XL-MS
• Expertise in the development and optimisation of protein characterisation methods, particularly intact mass analysis and peptide mapping for the assessment of purity, homogeneity and stability
• Experience on quantification approaches for peptides and proteins is highly desirable
• Solid knowledge of protein chemistry and related workflows, encompassing peptide and protein sample preparation, treatment, and handling
• Experience in peptide and protein separation and purification methods, including HPLC, SPE and dialysis
• Proficiency in mass spectrometry instrumentation, operation and maintenance (e.g. Orbitrap and qTOF platforms including ion mobility applications)
• Familiarity with bioinformatics tools and databases for protein identification and structural characterisation
• Strong data analysis and interpretation skills, particularly for protein mass spectrometry data
• Excellent written and verbal communication and presentation skills
• Experience in managing and carrying out long-term and short-term research projects, adhering to deadlines, and producing high-quality technical reports

Person Specification

The role requires an enthusiastic scientist who will contribute to the successful delivery of analytical R&D projects. You are encouraged to share your achievements through relevant scientific publications, reports and presentations. The following person specifications are required:

• Capacity to handle both extended and brief projects
• Passionate and innovative scientist
• Self-reliant and self-motivated great teammate
• Excellent interpersonal skills
• Strong attention to detail and a proactive attitude towards learning
• Appreciation for working within a quality system and knowledge of good laboratory practice

The job holder will be able to demonstrate the following behaviours in line with LGC’s values: 

Passion, Curiosity, Integrity, Brilliance, Respect

About The National Measurement Laboratory  

Measurement matters, as it affects everything from food and drink to medicine.  

At the NML we have a strong heritage in measurement science. We are the UK’s designated institute for chemical and bio measurement, and the home of the Government Chemist. 

The Government Chemist role was created in 1909 and now it oversees the statutory function of referee analyst within the UK, resolving disputes over analytical measurements, particularly in relation to food regulatory enforcement. 

The UK was one of the pioneers within the global measurement community to recognise the need to address the new and developing challenges of measurement across chemistry and biology. In 1988, the then Government Chemist launched the first UK programme to develop a chemical and bio-measurement infrastructure and the NML was born. 

https://www.lgcgroup.com/uk-national-measurement-laboratory/ 

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Our Benefits 

25 days annual leave, generous pension plan, season ticket loans, buy/sell holiday scheme, life assurance, retail discounts and more.