ADME/DMPK Technical Expert

Syngenta Crop Protection is a leader in agricultural innovation, bringing breakthrough technologies and solutions that enable farmers to grow healthy and nutritious food while taking care of the planet. We offer a leading portfolio of crop protection solutions for plant and soil health, as well as digital solutions that transform the decision-making capabilities of farmers. Our 17,900 employees serve to advance agriculture in more than 90 countries around the world. Syngenta Crop Protection is headquartered in Basel, Switzerland, and is part of the Syngenta Group.

Our employees reflect the diversity of our customers, the markets where we operate and the communities which we serve. Regardless of your position, you will have a vital role in safely feeding an ever-increasing population while taking care of our planet. Join us and help shape the future of agriculture.

Are you a proactive problem solver with a passion for driving technical innovation? If so, we have good news as we are looking for an experienced DMPK/ADME Technical Expert to join our Analytical Metabolism and Methods (AMM) group within Product Safety. Within this role, you will make a key impact in projects by delivering innovative study designs to aid our understanding of the Absorption, Distribution, Metabolism and Excretion (ADME) and Pharmacokinetics (PK) and/or Toxicokinetics (TK) of chemicals in mammalian toxicology species. You will work within a highly collaborative team of study managers and technical experts, while applying your scientific expertise to interpret complex DMPK/ADME data for project teams, directly supporting the development and registration of sustainable crop protection products.  A recent example is the registration of TYMIRIUM® technology which protects crops against soil-borne pests.  Additionally you will build effective partnerships with Contract Research Organisations (CROs), directing external study execution and collaborating to resolve technical challenges to secure the timely delivery of externally placed studies. Key responsibilities will include:

• Overseeing CRO delivery: Ensuring the timely delivery of business critical data generated at CROs, while being responsible for study strategy documents, protocol design, evaluation of data and reviewing/authorising company reports.
• Delivering technical insights: Elucidating insights from ADME and PK/TK data and reporting expert conclusions to metabolism teams.
• Applying regulatory expertise: Utilising your expert knowledge and understanding of ADME, PK/TK as well as relevant global regulatory guidance documents and their implication to optimise and de-risk our study designs. Keeping abreast of changes to regulatory guidelines and requirements.
• Partnering with CROs: Independently providing technical guidance and problem-solving support to external suppliers, where appropriate, to facilitate transfer of technical knowledge.
• Driving continuous improvement: Leading or contributing to the creation and optimisation of new  processes, technical guidance documents and report templates to improve efficiency and consistency across the team.
• Serving as a scientific contributor within the ADME, PK/TK expert area, providing expertise to metabolism teams and other functional areas as required.

What we are looking for

• Minimum of a degree or equivalent in a biology- or chemistry-related discipline.
• Significant knowledge in the areas of DMPK/ADME, with expertise in pharmacokinetics and/or toxicokinetics.
• Familiarity of global Regulatory Test Guidelines (e.g. OECD 417) relevant to ADME and toxicokinetics studies conducted to GLP standards for the registration of crop protection chemicals.
• Experience in translating complex datasets into key safety or regulatory insights to inform decision making.
• Practical knowledge of quantitative PK/TK principles, including non-compartmental analysis (NCA), calculation of key PK/TK parameters.
• Proven ability to work collaboratively within diverse scientific teams (e.g., toxicologists, modellers, metabolism specialists) and with external stakeholders (industry, contract research or regulatory agencies) to achieve project goals.
• Capability to organise, prioritise, and track complex scientific deliverables across multiple projects, applying strong attention to detail and analytical thinking to solve problems in scientific experiments to maintain quality and delivery to agreed timelines.
• Excellent oral and written communication skills, with the ability to prepare technical reports and presentations to articulate complex technical matters clearly.
• Willingness to learn and ability to apply new skills promptly.
• In-depth understanding of in vitro and in vivo xenobiotic mammalian metabolism, including metabolite identification, metabolic pathway elucidation, and cross-species comparison would be desirable.
• Experience managing services delivered through third-party organisations, ensuring quality, milestone adherence, and budget discipline would be advantageous.

Our site

Jealott's Hill International Research Centre UK is situated in pleasant semi-rural surroundings between Bracknell and Maidenhead and is the place of work for approximately 800 Syngenta scientists and support staff. Jealott’s Hill is one of the main global research and development sites and key activities include research into discovery of new active ingredients, new formulation technologies, product safety and technical support of our product range.

What we offer

• Extensive benefits package including a generous pension scheme, bonus scheme, private medical & life insurance.
• Up to 31.5 days annual holiday.
• Large campus environment.
• A position which contributes to valuable and impactful work in a stimulating and international environment.  
• The chance to work as part of a global team to address the current and future needs of the agricultural sector.
• Learning culture and wide range of training options.

Syngenta has been ranked as a top 5 employer and number 1 in agriculture by Science Journal.

Syngenta is an Equal Opportunity Employer and does not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Learn more about our D&I initiatives here: https://www.syngenta.com/careers/working-syngenta/diversity-and-inclusion

Jealott’s Hill has Disability Confident certification.

We are committed to making all stages of our recruitment process accessible to all candidates and our Jealott’s Hill site are a Disability Confident Level 2 Employer. Please let us know if you need any assistance or reasonable adjustments throughout your application and we will do everything we can to support you.