Principal Scientist, Medicinal Chemistry

Position Summary:

PsiThera is seeking a talented and creative medicinal chemist with strong hands-on experience advancing discovery programs from hit identification through development candidate nomination. This candidate will bring deep expertise in synthetic and medicinal chemistry, with a demonstrated track record optimizing peptide therapeutics for oral delivery, particularly macrocyclic peptides. The role requires practical experience designing and synthesizing complex molecules, peptides and peptidomimetics; applying structure-activity relationship principles to improve potency, selectivity, stability, permeability, and ADME/PK properties; and using multiparameter optimization to balance efficacy, developability, and oral exposure. The candidate must be able to integrate computational modeling, structural information, biophysical data, and biological assay results into clear design hypotheses and translate those hypotheses into executable chemistry plans. Appointable candidates will also have experience directing chemistry CRO, leading teams and communicating decisions clearly to cross-functional teams to progress programs efficiently toward development candidates.