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Principal Scientist / Senior Principal Scientist - Peptide Synthesis

EnvedaHyderabad🇮🇳India

Quick overview

SeniorityLeader
Employment typeFull Time
Work modeOn Site
LocationHyderabad, India
LinearUnity

Job description

Let’s build the future of medicine—together.

Genome Valley, Hyderabad, India | Full-Time

YOUR ROLE

As Senior Principal Scientist / Principal Scientist, Peptide Synthesis at Enveda, you will build and lead our peptide synthesis group from the ground up. You will set up the lab, define synthesis, purification and QC standards, and grow a team of 3-4 chemists who turn sequences designed by our project teams into high-purity, well-characterised peptides for therapeutic programmes. The role starts hands-on at the bench and moves toward leadership as the team matures.

WHAT YOU'LL DO

  • Synthesise linear, cyclic, lipidated and modified peptides by Fmoc SPPS (manual, microwave and automated), including orthogonal on-resin chemistry for branching and cyclisation

  • Troubleshoot difficult sequences (aggregation, racemisation, aspartimide formation) and give the design team early feedback on synthetic feasibility

  • Guide preparative RP-HPLC purification, interpret HPLC and LC-MS data, and decide between re-purification, re-synthesis and release

  • Set up the lab: specify and qualify synthesisers and lyophilisers, write SOPs, and partner with CROs/CDMOs for scale-up

  • Hire, train and mentor 3-4 chemists; plan workloads, run technical reviews and build a strong safety culture

WHAT WE'RE LOOKING FOR

  • PhD in organic or peptide chemistry with 10-12 years of hands-on peptide synthesis experience, including 2-3+ years leading or mentoring a team

  • Deep Fmoc SPPS expertise (manual, automated and microwave) with demonstrated success on long, hydrophobic, cyclic, multi-disulfide and lipidated peptides

  • Strong LC-MS interpretation skills and experience scaling from mg to hundreds of mg or gram scale

  • GLP-1-type or macrocyclic peptide experience, or experience setting up a peptide lab, is a strong plus

  • Clear communicator who can explain the limits of peptide chemistry to non-chemists

    • We hire for trajectory, not just credentials. If you meet most of the above and care deeply about this problem, we want to hear from you.

ABOUT ENVEDA

    We're a clinical-stage, AI-enabled biotech discovering medicines four times faster than the industry standard. We recently raised $150M in a Series D, reached unicorn status, and advanced our first drug into Phase 2 trials.
    Forbes named us one of America's Best Startup Employers. Newsweek recognized us as a Top 100 Most Loved Workplace. We're building something rare — and we're just getting started!
If you’re passionate about innovation and impact, we encourage you to apply—even if you don’t meet every requirement.
Our Values: Curiosity | Agency | Journey | Charity | Unity
Benefits: Culture | Medical | Block Leaves | Work-Life Harmony
At Enveda, we’re building a place where everyone can do the best work of their life. We are an equal opportunity employer and value diversity in all its forms.
👉Apply now and join a team committed to shaping the future of drug discovery.
Enveda is protecting Job Seekers
We care deeply about creating a safe, respectful experience for every applicant, so we wanted to share a few guidelines to help you spot anything that doesn’t feel right. You’ll always meet real Enveda team members through video or in-person conversations before receiving an offer.
All communication from us will come from an @enveda.com or @envedabio.com email address. We’ll never ask you to purchase equipment, send money, or share sensitive banking details as part of any step in our recruiting process.
If something feels off or you’re unsure whether a message is truly from Enveda, please reach out at anytime at recruiting@enveda.com.

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