Scientist II / Senior Scientist, ADME

Position Overview

The Scientist II / Senior Scientist, ADME will contribute to the design and execution of nonclinical pharmacokinetics/PKPD/ADME strategies to support oncology drug candidates from discovery through development. This role will partner closely with cross-functional teams to deliver high-quality data that informs decision-making and regulatory submissions. Reporting to the Executive Director, Head of ADME, the Scientist II will work on multiple modalities, with a strong emphasis on ADC programs. 

Responsibilities

• Perform modeling and simulation, analyze PKPD and PK/TK data, and provide clear interpretation to inform program decisions.
• Design and execute stage-appropriate PKPD and ADME studies to support candidate selection, clinical development, and regulatory submissions.
• Collaborate with cross-functional teams to ensure integration of ADME considerations into program strategy and timelines.
• Participate in Translational Sciences and Development team activities, contributing scientific expertise in ADME.
• Represent the ADME function at internal and external meetings, in collaboration with senior scientists, communicating timelines, data, and implications effectively.
• Maintain awareness of evolving best practices and regulatory expectations in ADME sciences. 

Qualifications

• PhD in a relevant discipline with 0–3 years of industry experience in ADC PKPD and ADME, or MS with 5+ years relevant industry experience.
• Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred.
• Hands-on expertise in PKPD modeling, PK/TK analysis, and study design.
• Knowledge of both non-regulated and regulated bioanalysis. 

Knowledge and Skills

• Strong problem-solving skills with the ability to manage multiple projects in a fast-paced environment.
• Excellent communication skills, with the ability to present complex scientific data clearly to diverse audiences.
• Collaborative approach with the ability to work across disciplines to achieve program goals.
   

Level and compensation will be commensurate with relevant experience.